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Number eight Billy Vunipola has been left out of new head coach Steve Borthwick's 36-man England squad for the Six Nations.
Other high-profile omissions include experienced wings Jonny May and Jack Nowell.
Meanwhile Borthwick has recalled 95-cap veteran prop Dan Cole, 35, who last played for England in the 2019 Rugby World Cup final.
Northampton fly-half Fin Smith is one of five uncapped players in the squad.
"This is an exciting squad, with a blend of Six Nations experience and young talent, and includes players who are in excellent form in the Premiership," Borthwick said.
England Six Nations squad
Forwards: Ollie Chessum, Dan Cole, Ben Curry, Alex Dombrandt, Ben Earl, Ellis Genge, Jamie George, Joe Heyes, Jonny Hill, Nick Isiekwe, Maro Itoje, Courtney Lawes, Lewis Ludlam, George McGuigan, Bevan Rodd, Sam Simmonds, Kyle Sinckler, Mako Vunipola, Jack Walker, Jack Willis.
Backs: Elliot Daly, Owen Farrell, Tommy Freeman, Ollie Hassell-Collins, Dan Kelly, Max Malins, Joe Marchant, Alex Mitchell, Cadan Murley, Henry Slade, Fin Smith, Marcus Smith, Freddie Steward, Manu Tuilagi, Jack van Poortvliet, Ben Youngs.
More to follow.